Purpose of SALTOSE's Development Plan
Among the livestock industries, poultry industry has become an important food industry in many countries, and since around 1980, the world's livestock industry has been corporatized and production has greatly expanded. As a result, farms have become larger and more mechanized, and livestock are kept in large, dense herds, which has led to outbreaks of various infectious diseases that have had a major impact on livestock productivity. However, the use of antibiotics, antimicrobials, and antiparasitic agents increased, and for a time the benefits were enjoyed, but eventually residues of these antibiotics became noticeable in meat, eggs, and milk, and resistant bacteria increased, affecting even human health today.
In response to the current situation in the livestock industry, many companies around the world have recently been actively proposing alternatives to antibiotics, but, Prior to these, Saltose was developed about 25 years ago as an organic bioagent to replace antibiotics.
To develop a new functional bio-agent, we commissioned Dr. Keifuku Lin to conduct research, selected from the rich bacterial population (over 10,000 species) owned by the institute, and used original biotechnology beyond existing manufacturing technology to search for a highly functional enzyme-producing strain that could replace antibiotics, thereby confirming its functionality as a probiotic feed. AN was involved in the joint opening and marketing of the probiotic feed by providing the livestock industry with the demand and knowledge.
Purpose of SALTOSE Development
The objectives of the development of SALTOSE PRO are summarized as follows
1.To prevent the emergence of antibiotic-resistant bacteria and the crisis caused by the mass
use of antibiotics.
2. the need for a biocide that can substitute for antibiotics
3. To improve productivity of livestock production by improving the intestinal environment
4. Expectations for pro-biotic efficacy against pathogens and protozoa for which antibiotics are
ineffective
5. Efforts toward organic livestock products
6. Improvement of livestock farm environment by useful microorganisms and countermeasures
against odor and other pollution
7. Promotion of fermentation of manure composting, odor control, and suppression of pests
(flies, beetles) and harmful bacteria
8. increase harvest of arable crops by organic composting (with beneficial bacteria)
9. eradication of pathogens affecting humans (Salmonella, Campylobacter, E. coli, etc.)
Enzyme production
Germinated bacteria begin cell division, with cell divisions occurring about every 20 minutes.
At that time, each “Saltose” Bacillus subtilis produces a unique enzyme.
They produce proteases (proteases), starch degrading enzymes (amylases), NSP degrading enzymes (xylanases), fiber degrading enzymes (cellulases), lipolytic enzymes (lipases), chitin degrading enzymes (chitinases), cell wall degrading enzyme groups (Cell wall lyases) and other digestive and degrading enzymes.
The amount of enzymes produced is far greater than that of other living organisms.
Of these enzymes, Cell wall lyase (Multi enzyme) is the most characteristic enzyme.
This enzyme is not a single enzyme, but a generic name for a group of several enzymes, which damage and break down the strong structural components of the cross-linked glycoproteins that make up the cell walls of pathogenic bacteria, thereby disabling their ability to divide and multiply and preventing their growth into large groups that can cause disease in the intestine.
Chitinase is a chitinous protein that acts on chitin, a structural material in the cell walls of insect pests (beetles) and fly eggs that transmit pathogens that are difficult to break down, and is used to inhibit their growth. Chitinase acts on chitin, which is a structural material in the cell walls of pests (beetles) and fly eggs that carry pathogens that are difficult to decompose, and suppresses their generation. At the same time, it also helps to reduce the odor of the farm environment by inhibiting odor-producing bacteria.
Other enzymes work as well as or better than the various digestive enzymes used in today's compound feeds, and also promote digestion of feed and absorption of nutrients.
Saltose bacteria actively produce these enzymes when they multiply in the intestinal tract after ingestion, so continuous use is effective in turning the intestinal tract into an enzyme production factory.
Furthermore, the lactobacilli contained in “Saltose” are plant-derived lactococcus with active growth and proliferation, and they are a powerful ally against the existing beneficial bacteria in the intestines. This lactobacillus has long been well-known as a human intestinal regulator, and there are many stand-alone products of this bacterium, but “Saltose” contains it as a cooperative bacterium that plays an important role in the fermentation process.
Expectations for Probiotics are Worldwide
Poultry, swine, beef cattle, and dairy farming in our country have become increasingly susceptible to highly pathogenic bacteria that cannot be resolved with antibiotics. Salmonella, clostridium, and coccidia in chickens, pathogenic Escherichia coli in swine, chronic diarrhea, Escherichia coli in cattle, and Cryptosporidium in dairy are still problems. Although biocides are not antibiotics and their expected functionality may not be apparent in the short term, their sustained use may improve overall farm hygiene and reduce the risk of harmful bacterial contamination.
For example, over a long period of time, these beneficial Bacillus subtilis and Lactobacillus acidophilus bacteria can be carried into the farm through the mixed feed and manure from the entire barn where they are fed, covering the entire farm with beneficial bacteria and inhibiting the growth of bad bacteria in the barn and on the grass outside the barn, resulting in an overall bio-protection by the beneficial bacteria. The result is an overall bio-protection by beneficial bacteria.
This is the ideal sustainable farm common to the world.
How to use “SALTOSE"
The enzymes contained in “Saltose PRO” are highly active, fast-acting enzymes.
It has the power to act on bad bacteria immediately after ingestion, and Saltose bacteria also synthesize and secrete a large amount of enzymes continuously after being active and germinating in the intestines. There are more than 10 different types of enzymes contained and produced, and as mentioned earlier, Cell wall lyases are special enzymes. They are commonly referred to as cellulolytic enzymes, which break down cross-linkages in cell walls, and they act on Harmful bacteria, but do not affect Beneficial bacteria such as Lactic acid bacteria and Bifido bacteria.
The characteristic feature of live bacteria agents is that they self-propagate in the intestines. Saltose bacteria have particularly strong activity, so if there is enough time available on the farm, the constant addition of even a lower amount than recommended can be expected to fully demonstrate its functionality as a biocide.
In Japan, it is often used as a countermeasure against Coccidium and Clostridium during the egg-laying period in egg-laying chickens, and is expected to improve the egg-laying performance by maintaining the health of the chickens. In broilers, it is used during the rapid intestinal tract development period of pre-starters (especially from the first day of laying until 11 days of age) to achieve healthy intestinal tract growth, and is expected to improve body growth in the later stages by supporting feed digestion and nutrient absorption through enzymes produced by the broiler. We also recommend its use as a countermeasure during the withdrawal period before shipment. In flat-feeding poultry houses, it is also expected to improve the floor environment by supporting the functionality of SALTOSE bacteria in the bedding material that is discharged together with poultry litter.
Future Prospects
Recently, international efforts to combat bacterial resistance have been spreading rapidly, and various functional feeds have been introduced. At the same time, there are reports that in other countries, combined administration of biocides and enzymes is attracting particular attention as a way to achieve smart, sustainable livestock production. The unique functionality of “SALTOSE” is unique in the world, and as a pioneering combination biocide of multiple biocides and multiple enzymes, efforts have begun at a new stage in Japan as well. SunrenBios will continue to keep a close watch on a variety of information both in Japan and overseas, and suggest the possibilities of SALTOSE PRO as a solution to problems.